… Alteration of E-cadherin intercellular junctions accounts for the increased fluid secretions, …
and intercellular junctions, leading to increased permeability of the intestinal barrier in C. …

… This process probably involves a conformational change and insertion of the toxin into the …
of the intercellular junctions, and thus an increase in cell barrier permeability. Racinactivation …

… of the toxin to endothelial cells of the brain–blood barrier (BBB) … to be a postmortem change
rather than a true lesion [84]. … , the extracellular matrix and intercellular junctions [162]. NetB …

… Clostridium sordellii is a Gram positive, spore-forming … sordellii was first characterized in
1922 by Alfredo Sordelli … sordellii. Some initially considered it to be a pathogenic form of C. …

… reorganization and disrupts epithelial barrier integrity 100 4.1. … of protein toxins that enter
mammalian cells and covalently modify … Clostridium sordellii lethal toxin kills mice by inducing a …

… , and likely to change these through DNA recombination. … , increasing the permeability of
epithelial and endothelial cells (both … are unable to cross the blood–brain barrier. However, the …

… alter epithelial permeability [33,34]. To check if SB203580-mediated inhibition of TcsL might
be useful with regard to disease treatment, TcsL-induced loss of epithelial barrier … ’s modified …

Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB)
belong to the family of the “Large clostridial glycosylating toxins.” These toxins mono-O-…

… Other family members are Clostridium sordellii lethal (TcsL) … of barrier functions and integrity
of the intestinal epithelial cells (23… permeability appears to occur mainly by alteration of tight …

… specifically inhibited by Clostridium sordellii lethal toxin (LT). … to increased vascular
permeability, tissue edema and death … were not mediated by a change in cholesterol levels, we …